DNA → RNA → Protein - Base Pairing

The Central Dogma: DNA



RNA



Protein

1. The following is a sequence of DNA. Some bases are missing. Fill them in.

G A T T A C A __ __

C T A A __ __ T T G

2. The

following is a sequence of DNA. All bases are missing. Fill them in.

C T T C C G C A A

__ __ __ __ __ __ __ __ __

3. The following DNA sequence is undergoing Transcription. Fill in the appropriate bases on the DNA and RNA.

A T __ C __ G __ __ T C

__ __ A __ G __ U C __ __

4. The

following DNA sequence is undergoing Transcription. Fill in the appropriate bases on the RNA strand.

T A C C G G T T T A

__ __ __ __ __ __ __ __ __ __

5. The following RNA transcript is undergoing Translation. Fill in the appropriate bases to match anticodon with

codon.

AUG ACG GAG CUU CGG AGC AAA UAA

___ ___ ___ ___ ___ ___ ___ ___

Base Pairing – DNA and Transcription

For the audio version of the file, click this link: Base Pairing Worksheet Audio

The Central Dogma: DNA



RNA



Protein

6. Using the above mRNA codon/anticodon triplet codes as well as the chart at the bottom of the page, identify the

amino acids coded for by this sequence. Circle the start codon and square the stop codon.

AUG ACG GAG CUU CGG AGC AAA UAA

___

___ ___ ___ ___ ___ ___ ___

Reminders:

Bases in DNA: Adenine, Thymine, Cytosine, Guanine

Purines: A & G

Pyrimidines: C & T

Pairing: A  T

 G

Bases in RNA: Adenine, Uracil, Cytosine, Guanine

Pairing from DNA  RNA: A  U mRNA contains codons

 A tRNA contains anticodons

 G

Proteins: sequence of amino acids  from start codon to stop codon

Answers: 1) Top: AC Bottom: TG 2) GAAGGCGTT 3) Top: TCAG Bottom: UAGCAG 4) AUGGCCAAAU

5) UAC UGC CUC GAA GCC UCG UUU AUU 6) Met (start) Thr Glu Arg Arg Ser Arg Stop